Zinc Signaling

This third edition reflects the rapid development of zinc signaling research and presents the latest advances in understanding the molecular, physiological, and pathological roles of zinc. Zinc is recognized not only as an essential structural and catalytic component of numerous proteins but also as a dynamic intracellular and extracellular signaling mediator that regulates diverse biological processes.

The volume covers the biochemical principles of zinc signaling, zinc transporters and their structural basis, zinc sensing mechanisms, metallothioneins, protein homeostasis, and advanced zinc imaging technologies. It explores the roles of zinc signaling in stem cell biology, immunity and inflammation, metabolism, neurobiology, cardiovascular physiology, reproduction, and tissue morphogenesis, as well as its involvement in cancer, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and infectious diseases. Recent advances in structural and chemical biology, genetics, and imaging technologies are also highlighted, together with the emerging potential of zinc biology for the development of diagnostic biomarkers, therapeutic strategies, and precision medicine.

Contributed by distinguished experts in the field, this updated edition will be a valuable resource for researchers, clinicians, and students across the biological, medical, and pharmaceutical sciences.