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Histone Code and Beyond

Name: Histone Code and Beyond
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01560890
Price: 103.1 EUR
Availability: InStock
Author: Shelley Berger
ISBN: 9783540278573

New Approaches to Cancer Therapy

Shelley Berger

Osamu Nakanishi

Bernd Haendler

Jazyk

Angličtina

Kniha Pevná

Libristo kód: 01560890

Nakladateľstvo Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, február 2006

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, inc... Celý popis

Libristo kód: 01560890

249 b

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Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.