Simulating Protein Folding in Variable Environmental Conditions

Simulating Protein Folding in Variable Environmental Conditions: Transformation from Globular Proteins to Amyloids delves into the effects of external conditions upon the protein folding process. It considers how this can lead to amyloid formation and why proteins fold the way they do. The book presents the fuzzy oil drop model (FOD-M), which enables the measurements of external factors influencing the folding process and considers changed external conditions as the source for the misfolding process. It begins with an introduction to amyloid transformation and outlines the hypothesis of the model simulation before considering the role of environmental factors, including the water environment and membrane environment. This book is a useful resource for researchers interested in investigating protein folding across molecular biology, structural biology, biochemistry, computational biology and related fields.

• Offers a model for simulating amyloid transformation in silico
• Explores how external properties influence the structural rearrangement of proteins
• Considers various types of amyloids, including α-synuclein, transthyretin endorphin, prefoldin and chaperonin to demonstrate the role of external force in the protein transformation process