Principles of Molecular Pathology

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.Molecular biology has transformed the field of pathology by providing new insights into human diseases and new tools for the diagnosis and classification of disease. In Principles of Molecular Pathology, Anthony Killeen, md, phd, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted. Extensive bibliographies point the reader to the primary literature and the key references. §Cutting-edge and highly readable, Principles of Molecular Pathology illuminates for every pathologist, pathology resident, physician, and medical student the ongoing molecular revolution that is now transforming pathology and the practice of laboratory medicine.