Kontakt
Ako nakupovať
Doručenie
Nákupný poradca
Formulation of Glibenclamide Solid dispersion
Angličtina
118 b
Až 30 dní na vrátenie tovaru
Zákazníci tiež kúpili
/
Brožovaná
16.98
€
/
Brožovaná
49.56
€
/
Brožovaná
16.08
€
In present work attempts have been made to formulate solid dispersion of Glibenclamide, by PEG 6000 and PVP K30. which is used as Antidiabetic agent in case of type II diabetes. Solid dispersion were prepared using polymer with PEG 6000 and PVP K30 in different ratio (1:1, 1:5, 1:10) by physical mixture, co-evaporation and melting method. In-vitro dissolution were carried out by keep in the phosphate buffer (pH 7.2) at interval of 4 hr for solid dispersion of different ratio (i.e. 1:1, 1:5, 1:10) & three different methods and results were good dissolution for solid dispersion by co-evaporation, method (CE 1:10) found to be (97.14%). The compatibility evaluations were performed by FTIR spectroscopy and DSC analysis. Both studies implies that the drug and polymers are compatible with each other. Assay were carried out for finally selected solid dispersion and the result were found to be 99.04% by UV Spectrophotometer. Stability studies were carried out by keeping the solid dispersion (CE 1:10) at room temperature and at a 40o C + 2oC / 75 + 5% RH (stability chambers) for 90 days results showing no change in physical appearance and invitro dissolution profile.
Informácie o knihe
Angličtina
Darujte túto knihu ešte dnes
Je to jednoduché
1 Pridajte knihu do košíka a vyberte možnosť doručiť ako darček 2 Obratom Vám zašleme poukaz 3 Knihu zašleme na adresu obdarovanéhoMohlo by vás tiež zaujímať
/
Brožovaná
17.39
€
/
Brožovaná
12.26
€
/
Brožovaná
20.20
€
Ahoj! Som Libroamiko, tvoj knižný radca.
Ako ti môžem pomôcť?