Autophagy in Health and Disease

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The editors expand the coverage from the 1st edition – focused on the cardiovascular system, where research started - to all cell types and organ systems. Starting with the foundational concepts, part I provides an overview of the area, including: history, trajectory of the research field, mechanisms of autophagy, and its regulation. Part I also cover developmental aspects, including: stem cells, embryogenesis, hematopoiesis, and paligenosis. Part II is devoted to applications to several systems in the human body including: Metabolic control and Diabetes, Cardiovascular, Nervous, Immune, Gastrointestinal, and Skeletal. The final chapters provide additional disease considerations, covering cancer, longevity, disease mechanisms, and the therapeutic targeting of Autophagy. This book is invaluable to anyone new to the field, as well as established investigators who are looking for a broader understanding of autophagy outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiologyExtended coverage of the mechanisms mediating autophagyCoverage the role of autophagy in stem cells and iPSCs, as well as the regenerative process of “paligenosis” New sections on Metabolic Control and Diabetes include separate chapters covering the liver, adipose, pancreas, and skeletal muscleNew section will on the nervous system and neurodegenerationNew chapter on cancer and cancer therapeutics