Advanced Physiology and Pathophysiology

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Concise and well-organized, this advanced physiology and pathophysiology text promotes deep understanding of key pathophysiological concepts and relates them to major disorders commonly seen in practice. The second edition offers new features that add to its value in preparing the student clinician to care for patients with a broad variety of disorders, as well as coverage of new scientific advances.

With the aim of preparing students to be well-informed and confident decision makers in primary care settings, the text provides the key knowledge required to master pharmacology for prescriptive practice. Addressing both healthy organ function and disease-associated changes, it details and illustrates the cellular structure and function of each organ system and mechanisms of associated major clinical disorders. It examines the reasons patients often present with particular symptoms, the rationale for ordering specific diagnostic tests and interpretation of the results, and common management strategies that proceed from the underlying pathology. The text is replete with case studies to illustrate concepts, more than 500 images, key points to reinforce knowledge, and a glossary of essential terminology. Comprehensive instructor resources accompany the text. Print purchase includes online access to CourseConnect, an interactive learning platform.

New to the Second Edition:

• Physiology of pregnancy, labor, and delivery


• Expanded coverage of neonatal and pediatric development and vulnerabilities


• Methylation patterns of cell-free DNA (epigenetics) in oncology practice


• Expanded coverage of fluid and electrolyte balance


• Increased content on the social determinants of health


• Introduction of the exposome concept in human disease


• New content on biological and psychosocial aspects of human sexual development and variations relevant to LGBTQ+-centered care

Key Features:

• Includes comprehensive lifespan considerations with key insights from specialists in pediatric and geriatric pathophysiology


• Integrates critical-thinking questions and case studies to promote discussion and information synthesis


• Provides unique "Bridge to Clinical Practice" in each chapter to translate science to practical patient care


• Includes more than 500 images to illustrate complex scientific concepts


• Summarizes content with key points at the end of each chapter


• Print purchase includes online access to CourseConnect, an interactive learning platform

CourseConnect Features:

• Interactive chapter modules with lessons, case studies, and quizzes


• Flashcards, game center, and discussion board


• Analytics dashboard with strengths and weaknesses and progress tracking