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Medication use is at an all-time high, especially in aging populations, and medication harm is one of the few preventable causes of harm in medicine. Polypharmacy, Appropriate Prescribing, and Deprescribing: A Clinician's Guide is a first-of-its kind resource that provides clinicians and trainees with current, authoritative guidance and skill-building insights on how and when to use the right medications, and how and when medications should be stopped. This timely, instructive text is a must-have reference for a wide variety of healthcare practitioners and is particularly useful in the outpatient office where the majority of chronic medication prescribing and reviewing takes place. The text is an essential educational resource now and in the future as the burden of polypharmacy continues to expand globally. - Addresses polypharmacy not only in geriatric patients, but across the lifespan, including younger adults, patients with intellectual and developmental disabilities, and those with life-limiting conditions- Approaches polypharmacy from a unique, systems- and process-based approach, covering each system's polypharmacy nuances in addition to evidence-based polypharmacy criteria, and teaching skills that are repeatable throughout different clinical disciplines and systems of the body- Contains decision-making algorithms in each systems-based chapter, including polypharmacy related to CNS, cardiovascular, endocrine and metabolic, hematology/oncology, and infectious disease, as well as polypharmacy in palliative care- Includes most common scenarios encountered in each body system, covering how to work through classic examples of the polypharmacy problems that occur in that system. These examples are individually valuable because of their commonality, but also reinforce a structured approach toward any other polypharmacy problem- Discusses practical, real-world issues such as how to manage polypharmacy in short clinical visits, and future directions in deprescribing and medication optimization- Any additional digital ancillary content may publish up to 6 weeks following the publication date